anabol dianabol/methandienone review

Contraindications:
Hypersensitivity, pregnancy, lactation, chronic heart failure , myocardial infarction, renal insufficiency anabol dianabol/methandienone review, severe anemia, liver failure, decompensated cirrhosis, autoimmune diseases (including autoimmune hepatitis), not treatable thyroid disease, severe depression with suicidal intentions, children and Youth age (up to 18 years).

Precautions
Women of childbearing age (pregnancy is not desirable), decompensated diabetes (with bouts of ketoacidosis); chronic obstructive pulmonary disease, pulmonary embolism, chronic heart failure, thyroid disease (including hyperthyroidism), bleeding disorders, thrombophlebitis, mielodeprescia, hemoglobinopathies (including thalassemia, sickle-cell anemia), depression, suicidal (including history).

Dosing and Administration
The drug is taken by mouth without chewing and drinking water, along with the food intake.

Duration ribavirin combination therapy with alpha interferon, is typically 24 – 48 weeks. In addition, for treatment-naïve patients with duration of the course is at least 24 weeks and patients with genotype 1, the course duration is 48 weeks. In patients refractory to monotherapy with alpha – interferon, and for relapsed disease course duration is at least 6 months.

Side effect
On the part of the nervous system: headache, insomnia, asthenic syndrome, depression.

Cardio-vascular system: decrease in blood pressure, bradycardia, cardiac arrest.

From the side of hematopoiesis: hemolytic anemia, leukopenia, neutropenia, granulocytopenia, thrombocytopenia.

From the digestive system: loss of appetite, nausea, hyperbilirubinemia.

Allergic reactions: urticaria, angioedema, bronchoconstriction, anaphylaxis, skin rash.

Other: hair loss.

Overdose
possible increased severity of side effects. Treatment : removal of the drug, symptomatic therapy.

Interaction with other drugs
When combined ribavirin and alpha – interferon indicated synergy of their action.

In clinical use of different drugs at therapeutic doses in combination with ribavirin showed no significant interactions.

Purpose ribavirin zidovudine treatment during and / or simultaneously with stavudine existing  infection accompanied by a decrease in phosphorylation of these drugs, resulting in  viremia and treatment regimen requires a change. Not detected interaction ribavirin and nucleoside reverse transcriptase inhibitors or protease inhibitors. It is therefore possible joint use of these drugs and ribavirin for the treatment of patients co-infected  and hepatitis .

Medicaments containing compounds of magnesium and aluminum, simethicone reduces the bioavailability of the drug.

Specific guidance
should be considered teratogenic, men and women of reproductive age during treatment and for 7 months after the end of treatment should use effective contraception.

Laboratory tests (complete blood count with leukocyte and platelet count, determination of electrolytes, creatinine, liver function tests) should be carried out before the start of therapy, at 2 and 4 weeks, and then on a regular basis.

During treatment with ribavirin maximum decrease in hemoglobin in the majority of cases it occurs after 4-8 weeks of starting treatment. By reducing the hemoglobin is less than anabol dianabol/methandienone review should be temporarily reduce the dose of ribavirin at 400 mg per day, with a decrease in hemoglobin of less than 100 mg / ml dose should be reduced to 50% of the original. In most cases, the recommended dose modifications provide restoration of hemoglobin levels. By reducing the hemoglobin is less than 85 mg / ml should stop taking the drug.

In acute manifestations of hypersensitivity (urticaria, angioedema, bronchoconstriction, anaphylaxis) use of the drug should be discontinued immediately. Transient rashes do not serve as grounds for interruption of treatment.

During treatment, those experiencing fatigue, drowsiness or disorientation, should refrain from driving motor vehicles and activities potentially hazardous activities that require high concentration and psychomotor speed reactions.

In connection with a possible worsening of renal function anabol dianabol/methandienone review in elderly patients prior to use of the drug is necessary to determine kidney function, in particular creatinine clearance.