anabol tablets 5mg/1000 methandienone
Studies in patients, showed similar pharmacokinetic parameters of abacavir, lamivudine and zidovudine when used in a fixed combination (zidovudine + lamivudine) in conjunction. In addition, these parameters are similar to those which were obtained in the investigation of bioequivalence in healthy volunteers.
A comparative study of bioequivalence and combination of lamivudine 150 mg zidovudine 300 mg tablets taken together on an empty stomach, as well as the impact assessment food on the rate and extent of absorption. It is shown that in the fasting Combivir bioequivalent lamivudine 150 mg in combination with zidovudine 300 mg, used as single agents.
A comparative study of bioequivalence and combinations of lamivudine 150 mg zidovudine 300 mg and abacavir dose 300 mg, taken together, as well as the assessment of the impact of food on the rate and extent of absorption. Results of the analysis parameters indicate bioequivalent lamivudine 150 mg in combination with zidovudine 300 mg and abacavir 300 mg of individual drugs, and the reception food did not lead to clinically meaningful changes in pharmacokinetics parameters. Absorption When administered lamivudine, abacavir and zidovudine is rapidly and well absorbed from the gastrointestinal tract. The absolute bioavailability of lamivudine, abacavir and zidovudine after ingestion in adults is 80-85%, respectively, 83% and 60-70%. Food intake reduces the rate of absorption of Trizivir active substances, resulting in a slight decrease in the maximum concentration and an increase in the time to reach maximum concentration for approximately 1 hour, but is not reflected in the area under “concentration-time” . These changes pharmacokinetic parameters are not clinically significant, so Trizivir can be taken with food or on an empty stomach. Distribution The volume of distribution of lamivudine, abacavir and zidovudine when administered intravenously is an average of 1.3, 0.8 and 1.6 l / kg respectively.Lamivudine anabol tablets 5mg/1000 methandienone basic protein binding to plasma, albumin, slightly ( in vitro at least 36% serum albumin), and therefore pharmacokinetics of lamivudine is linear. Zidovudine is bound to plasma proteins at 34-38%.According to studies in vitro , in therapeutic doses abacavir binds to serum proteins to approximately 49%.
The interaction Trizivir active ingredients with other drugs by their displacement from the compound to plasma proteins is unlikely. Thus should also not enter into such a variant interaction with drugs, which are mediated by displacement of their connection with the plasma proteins. Lamivudine, zidovudine and abacavir penetrate the blood-brain barrier and is found in the cerebrospinal fluid. The ratio of the concentration of lamivudine and zidovudine serum to the appropriate concentration of the drug in theafter 2 to 4 hours after ingestion of an average of about 0.12 to 0.5 for lamivudine and zidovudine. The true extent of penetration of lamivudine , as well as the clinical significance of this phenomenon has not yet been established. According to studies patients, abacavir penetrates well into anabol tablets 5mg/1000 methandienone, and the of abacavir in is 30-44% of abacavir in plasma. In Phase 1 clinical trial to study the pharmacokinetics of abacavir indicated that at 1.5 hours after administration of a dose of abacavir 300 mg 2 times a day, its concentration in anabol tablets 5mg/1000 methandienone is 0.14 g / ml.When applying abacavir 600 mg 2 times a day, its concentration in increased from 0.13 ug / ml after 0.5-1 hours after administration, up to 0.74 g / mL within 3-4 hours.