d-ball steroid information

When administered orally d-ball steroid information is rapidly and completely absorbed from the digestive tract. The half-life of 5-10 hours. Trihexyphenidyl is highly lipotropic well pass through the blood-brain and placental barriers. Provided with breast milk. It is hydrolyzed under the influence of a nonspecific tissue esterases.Report the news: a small amount in an unmodified form, and the main part – in the form of metabolites.

Indications
Parkinsonism of various etiologies; movement disorders associated with lesions of the extrapyramidal system.

CONTRAINDICATIONS
Hypersensitivity to any component of the drug, mechanical stenoses of the gastrointestinal tract, megacolon, angle-closure glaucoma, urinary retention, prostatic hyperplasia (with the presence of residual urine), pulmonary edema, dementia, children’s age (12 years), pregnancy, lactation .

Precautions : decompensated heart disease, kidney or liver disease, tachycardia, tachyarrhythmia, hypertension, psychosis, acute myocardial infarction, advanced age.

Dosing and Administration
Inside, before a meal or during a meal.
The initial dose – 0.5 – 1 mg / day. The dose is gradually increased to 1 – 2 mg every 3 -. 5 days
Usual maintenance dose – 6 to 10 mg per day, divided into 3 – 4 doses. In severe cases it may be necessary to increase the dose of 16 mg to 12, divided into 3 – 4 divided doses. The d-ball steroid information┬ámaximum single dose – 10 mg daily – 16 mg.

Side effect On the part of the nervous system : headache, dizziness, irritability, delusions, hallucinations, fatigue, poor concentration, psychoses. Effects due to anticholinergic activity : dry mucous membranes of the mouth, paresis of accommodation, increased intraocular pressure, constipation, urinary retention ( including the prostate cancer), tachycardia, decreased sweating. From the digestive system : nausea, vomiting. Allergic reactions : skin rash. Other : purulent parotitis (due to xerostomia), flushing of the skin, decreased muscle tone, the development of drug dependence is possible.

 

Overdose
Large doses of trihexyphenidyl cause blockade postganglionic endings of the parasympathetic nervous system, poisoning the picture corresponds to the poisoning of atropine (mydriasis, dryness of the oral mucous membranes, tachycardia, atony bowel and biliary tract ,, fever). Disorders of the central nervous system symptoms are expressed in mental and motor excitation may develop coma or paralysis of the respiratory center. Treatment of poisoning : there is no specific antidote. First Aid: gastric lavage, activated charcoal, symptomatic treatment.

Drug Interactions
In a joint application with the H1-histamine blockers, phenothiazine derivatives, tricyclic antidepressants increase the expression of peripheral anticholinergic effects with chlorpromazine -. May reduce its concentration in the plasma
under the influence of reserpine antiparkinsonian action trihexyphenidyl decreases (depletion of reserves of dopamine in the central nervous system, activation of cholinergic neurons ).
Levodopa increases the activity of anti-trihexyphenidyl. When applied with both drugs levodopa dosage should be reduced. Usually it is sufficient 3 – 6 mg trihexyphenidyl per day, divided into two stages.
Under the influence of inhibitors of monoamine oxidase may increase the anticholinergic action of anticholinergics used in parkinsonism.
In an application trihexyphenidyl reduced effect used sublingual nitrates (due to dry mouth).
Depressive action alcohol and drugs that affect the d-ball steroid information central nervous system may be enhanced when used with trigeksifenidilom.

Cautions
In the period of treatment should refrain from driving motor vehicles and activities potentially hazardous activities that require high concentration and psychomotor speed reactions. Treatment should not be stopped suddenly. If you are taking the drug there is dryness of the mouth, it is desirable to take before eating, as otherwise it may appear nausea.
After treatment, or in the event of alternative treatment doses of trihexyphenidyl should be reduced gradually.
Patients older than 60 years is prescribed with extreme caution due to the sensitivity to the drug – the possibility of deterioration of memory and thinking. When large doses of the drug or in patients with predisposing factors (atherosclerosis, advanced age or patients who previously appeared idiosyncrasy to any drug) can appear mental disorders (unnatural increase in mood, agitation, irritability), vomiting or nausea . In these cases it is necessary to stop treatment. During d-ball steroid information┬álong-term treatment severity of side effects caused by anticholinergic effect, decreases. It is necessary to periodically monitor eye pressure.